N-Methyl-D-Aspartate Receptors

A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

Also Known As:

NMDA Receptors; Receptors, N-Methyl-D-Aspartate; N-Methylaspartate Receptors; Receptors, N-Methylaspartate; N Methyl D Aspartate Receptor; N Methyl D Aspartate Receptors; N Methylaspartate Receptors; NMDA Receptor Ionophore Complex; Receptor, N-Methyl-D-Aspartate; Receptor, NMDA; Receptors, N Methyl D Aspartate; Receptors, N Methylaspartate; N-Methyl-D-Aspartate Receptor; NMDA Receptor; NMDA Receptor-Ionophore Complex; Receptors, NMDA

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Membrane Transport Proteins: 606
      - Ion Channels: 6936
        Ligand-Gated Ion Channels: 224
        Ionotropic Glutamate Receptors: 398
        N-Methyl-D-Aspartate Receptors: 10546
  - Membrane Proteins: 10262
    - Membrane Glycoproteins: 2277
      - Ion Channels: 6936
        Ligand-Gated Ion Channels: 224
        Ionotropic Glutamate Receptors: 398
        N-Methyl-D-Aspartate Receptors: 10546
    - Cell Surface Receptors: 2156
      - Neurotransmitter Receptors: 577
        Amino Acid Receptors: 25
        Glutamate Receptors: 2732
        Ionotropic Glutamate Receptors: 398
        N-Methyl-D-Aspartate Receptors: 10546
    - Membrane Transport Proteins: 606
      - Ion Channels: 6936
        Ligand-Gated Ion Channels: 224
        Ionotropic Glutamate Receptors: 398
        N-Methyl-D-Aspartate Receptors: 10546

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Drug/Important Bio-Agent (IBA)